Acute Coronary Syndrome
Conditions
Keywords
ACS, CR, PCI, Platelet funtion, Ticagrelor
Brief summary
The purpose of this study is to compare the efficacy and safety of ticagrelor with clopidogrel
Detailed description
180 elective percutaneous coronary intervention patients with clopidogrel resistance were randomized to three groups, Group 1:received clopidogrel 75mg qd ;Group 2:received clopidogrel 150mg qd ; Group 3:received ticagrelor 90mg bid after PCI.Platelet funtion were tested by flowcytometric vasodilator-stimulated phosphoprotein(VASP) analysis before PCI,and 3days,7days and 1 month after PCI,respectively.The aim of our study is to compare the efficacy and safety of ticagrelor with clopidogrel
Interventions
DRUGClopidogrel
After 600mg loading dose, 75mg or 150mg Qd
DRUGTicagrelor
90mg Bid
Sponsors
General Hospital of Chinese Armed Police Forces
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* 1.Clinical diagnosis of ACS 2.undergoing PCI 3.with clopidogrel resistance
Exclusion criteria
* 1.any contraindication against the use of clopidogrel and ticagrel 2.Contradiction to aspirin and contrast medium 3.Life expectancy less than 1 year 4.Tumor or inflammatory diseases5. fibrinolytic therapy within 24 hours before randomization 6.a need for oral anticoagulation therapy 7. an increased risk of bradycardia 8.concomitant therapy with a strong cytochrome P-450 3A inhibitor or inducer 9.a history of asthma.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PRI | post operative 1 month | Platelet funtion were tested by flowcytometric vasodilator-stimulated phosphoprotein(VASP) analysis.And a platelet reactivity index (PRI) was calculated. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Major adverse cardiac events(MACEs) | follow-up for 1 month | cardiovascular death,angiographically confirmed stent thrombosis, recurrent acute coronary syndrome defined by the American College of Cardiology/American Heart Association guidelines,and recurrent revascularization by either coronary angioplasty or bypass surgery |
| major and minor bleeding | follow-up for 1 month | Major bleeding was defined as intracranial bleeding or clinically-overt bleeding associated with a decrease in hemoglobin of 50 g/L, according to the Thrombolysis inMyocardial Infarction (TIMI) criteria .Minor bleeding was also defined according to TIMI criteria . |
Countries
China
Contacts
Primary Contacthuiliang liu, doctor
Backup Contactyujie wei, doctor
Outcome results
None listed