Lung Cancer, Non Small Cell Lung Cancer, Chronic Obstructive Pulmonary Disease
Conditions
Keywords
PET/CT, 18F-fluoro-2-deoxyglucose, lung neoplasms, respiratory motion
Brief summary
Fluorodeoxyglucose (FDG) positron emission tomography (PET) is now widely used for cancer imaging purpose, notably for preoperative work-up. It aims at visualizing organs metabolism. In case of cancer, metabolism is, classically, increased and some hot spots are visible on PET images. Because of respiratory motion some lung tumours (especially the smallest ones) can be falsely interpreted by the clinician. The investigators developed a respiratory-gated PET method in order to reduce the motion issue. The investigators designed a study to investigate its effect on lung cancer (primary or metastasis) to check if it improves the sensitivity/specificity of PET imaging of the lungs. To that aim, patients presenting a lung nodule on a CT examination can be proposed to participate this study. After the standard PET acquisition (acquired in free-breathing), an additional 10 minutes respiratory-gated PET acquisition is performed without additional injection. After that, a breath-hold (\ 10s) CT is performed.
Interventions
OTHERmedical imaging
After fasting for at least 6 hours, normal glucose blood level was checked and each patient received an intravenous injection of 18F-FDG (5MBq/kg). After a 60-minute uptake phase in a quiet environment, patients underwent the PET/CT examination. Whole-body PET/CT (Ungated session) The Ungated acquisition consisted in a whole-body, free-breathing CT followed by standard multistep PET, used as routine clinical practice in the department. Respiratory-gated PET/CT (CT-based session) The CT-based method consisted in an additional single-step, 10-minute List Mode respiratory gated PET acquisition followed by an end-expiration breath-hold CT added to the end of the clinical protocol, with continuous respiratory signal recording during these examinations.
Sponsors
Centre Hospitalier Universitaire, Amiens
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patient has one or more lung lesion(s) less than 35 mm visible on a CT image * age : over 18 years * patients gave their written informed consent
Exclusion criteria
* pregnancy * patient has at least one lesion more than 35 mm in its great axis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lesion SUVmax | Day 1 | For each CT nodule, observer has to report the corresponding (maximum Standardized Uptake Value)SUVmax on ungated and CT-based images (even if there is no obvious uptake) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lung function test | Day 0 | Patients undergo lung function test including measures of: * total lung capacity * residual volume * forced expiratory volume * forced vital capacity |
Countries
France
Outcome results
None listed