A New Diet for Patients With Autosomal Dominant Polycystic Disease (ADPKD)

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01810614

Enrollment

Registered

2013-03-13

Start date

2013-02-28

Completion date

2014-11-30

Last updated

2015-08-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autosomal Dominant Polycystic Kidney Disease

Keywords

ADPKD, PKD, Kidney Disease, ADPKD diet

Brief summary

Recent evidence has shown that kidney volume predicts the likelihood of developing renal insufficiency over a finite length of time in ADPKD, suggesting a linkage between the growth of cysts and the harm they do to kidney function. Recent studies indicate that the rate of kidney volume increase is hastened by excess dietary protein, salt, and potential net acid precursors, and slowed by increased water intake sufficient to lower plasma vasopressin levels. Diets are commonly prescribed to treat ADPKD and other renal patients with disease near the end-stage, but there is currently no specific diet prescription that takes potentially harmful dietary elements into account for ADPKD patients in the earliest stages of the disease. This study will examine a novel diet for ADPKD created by the researcher termed the ADPKD diet.

Interventions

OTHERADPKD Diet

Diet specifically designed for people with ADPKD

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Have not been prescribed dietary restrictions or enhancements * Blood pressure \<135/85 mmHg with or without specific treatment * Willingness to participate for at least one month * Diet history consistent with the excretion of \>30 mEq NAE / day based on usual dietary intake

Exclusion criteria

* Other active diseases requiring pharmacologic agents * Unstable weight (+/- 2 kg) for 3 months prior to enrollment * Food allergies * Pregnancy or lactating * Confounding medications, i.e. bicarbonate, citrate * Individuals who do not consume meat for personal, religious, or health reasons.

Design outcomes

Primary

Measure	Time frame	Description
ADPKD diet impact on net acid excretion	Change from Baseline to Day 36	The difference in net acid excretion from a participants regular diet and the ADPKD diet

Secondary

Measure	Time frame	Description
Acceptance of ADPKD diet	36 days	Ease with which diet will be embraced by participants
Kidney injury markers	Change from Baseline to Day 36	Change in urine markers of renal injury in participants

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 14, 2026