Function and Modulation of Fibulin-1 Assembly in Nucleus of Corneal Fibroblasts

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01808495

Enrollment

Registered

2013-03-11

Start date

2012-08-31

Completion date

2015-08-31

Last updated

2015-08-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Function of Mitomycin C in Cornea

Keywords

Human corneal fibroblasts, Fibulin-1, Nuclear accumulation

Brief summary

The purpose of this study is to investigate the role of nuclear Fibulin-1 (FBLN1) in Human Corneal Fibroblasts under treatment of mitomycin C (MMC).

Interventions

DRUGMitomycin C

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

* The frozen storage cells in liquid nitrogen were amplified from the residual corneal rim of the donors with more than 20 years old following penetrating keratoplasty.

Exclusion criteria

* The donors were younger than 20 years old.

Design outcomes

Primary

Measure	Time frame
Modification of nuclear Fibulin-1 accumulation in suppressing gene expression	3 days post mitomycin C treatment

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026