The Use of Capsaicin Challenge for Diagnosis, Monitoring and Follow-up of Chronic Cough.

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01807832

Enrollment

Registered

2013-03-08

Start date

2013-03-31

Completion date

2013-12-31

Last updated

2013-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Cough

Keywords

chronic cough, cough reflex hypersensitivity, capsaicin

Brief summary

The purpose of this study is to determine whether the capsaicin challenge can improve the diagnosis, treatment, monitoring and follow-up in patients with chronic cough.

Detailed description

Capsaicin is administrated in incremental concentrations with two inhalations of normal saline solution. Patients are instructed to exhale to functional residual capacity and than to inhale through the mouthpiece for 1 second (single breath inhalation). The number of coughs in the first 10 seconds after each inhalation is counted. C2; the concentration of which the patient responded by 2 coughs, C5;the concentration of which the patient responded by 5 coughs. The challenge ends at C5.

Interventions

OTHERcapsaicin challenge

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Patients with persisting cough for more than 3 months, without known respiratory or lung diseases

Exclusion criteria

* Diagnosis of respiratory or lung diseases of any kind

Design outcomes

Primary

Measure	Time frame
cough reflex hypersensitivity	3 months

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026