Genetic Biomarkers in Tissue Samples From Patients With Osteosarcoma

Observational - Gene Discovery in Osteosarcoma

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01807143

Enrollment

Registered

2013-03-08

Start date

2010-01-31

Completion date

Unknown

Last updated

2016-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteosarcoma

Brief summary

This clinical trial studies genetic biomarkers in tissue samples from patients with osteosarcoma. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer

Detailed description

Study Subtype: Ancillary/Correlative Observational Study Model: Cohort Time Perspective: Retrospective Biospecimen Retention: Samples With DNA Biospecimen Description: Tissue Study Population Description: Samples from the COG Sampling Method: Non-Probability Sample PRIMARY OBJECTIVES: I. To use PET sequencing to analyze DNA from ten human primary osteosarcoma samples, along with matched normal tissue where available. OUTLINE: Tissue samples are analyzed for translocations and deletions and analyzed using polymerase chain reaction (PCR) or fluorescence in situ hybridization (FISH).

Interventions

OTHERlaboratory biomarker analysis

Correlative studies

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Samples from the COG tissue repository

Design outcomes

Primary

Measure	Time frame	Description
Mapping and filtering of paired tags	Up to 2 years	Mapping of paired tags to reference genomes to identify aberrant pairs, caused by translocations, insertions, deletions and inversions.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026