Study of Association Between Digital Osteoarthritis and Lower Limb Osteoarthritis

Study of the Association Between Digital Osteoarthritis and Lower Limb Osteoarthritis (Knee and Hip) in Terms of Severity and Evolution - Khoala Group Ancillary Project / Cohort Khoala

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01805349

Acronym

Khoala

Enrollment

479

Registered

2013-03-06

Start date

2013-11-04

Completion date

2013-12-01

Last updated

2026-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Digital Arthrosis

Brief summary

Among the risk factors for lower limb osteoarthritis, if obesity is probably the most studied, digital osteoarthritis received increasing interest in recent years. Recent publications have highlighted a link between obesity and digital osteoarthritis, but also a very probable link between digital osteoarthritis and structural progression of knee osteoarthritis. Few data including hip exist and need to be confirmed on larger scale studies. We have with "Khoala" a national multiregional cohort of symptomatic gonarthrosis and coxarthrosis representative of the general population (which is rarely the case in the literature) including X ray, clinical and biological follow-up (hips and / or knees).

Interventions

RADIATIONHand X-rays

Hand X-rays to assess the digital arthrosis

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

40 Years to 75 Years

Healthy volunteers

Inclusion criteria

* men or women aged 40 to 75 years * with symptomatic osteoarthritis of the hip and / or knee (femoro-tibial), unilateral or bilateral * with a confirmed diagnosis (criteria of the American College of Rheumatology :ACR) and Kellgren and Lawrence radiological stage ≥ 2.

Exclusion criteria

* painful hip or knee prosthesis * osteotomy in the past

Design outcomes

Primary

Measure	Time frame	Description
Kellgren and Lawrence score	Change at 2 years	Kellgren and Lawrence score for hip or knee

Secondary

Measure	Time frame
Harris score	Harris score at 2 years

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 1, 2026