Myocardial Blood Flow by 15O Water PET

Validation of Computed Tomography Myocardial Perfusion Imaging Using Quantification of Myocardial Blood Flow by Positron Emission Tomography With 15O-water

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01805193

Enrollment

Registered

2013-03-06

Start date

2012-12-31

Completion date

2019-01-31

Last updated

2019-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Heart Disease

Keywords

Coronary heart disease, computed tomography myocardial perfusion, positron emission tomography, oxygen 15 labelled water, myocardial perfusion, myocardial blood flow

Brief summary

Coronary heart disease is a very common condition caused by narrowings in the blood vessel supplying the heart. the investigators are studying new tests to diagnose heart disease. In this study the investigators plan to investigate a special scan called a PET/CT (Positron emission tomography/computed tomography) and a new type of CT (Computed tomography) scan to tell us about the flow of blood to the heart muscle.

Detailed description

Participants will undergo PET/CT with oxygen-15 labelled water and computed tomography myocardial perfusion imaging.

Interventions

OTHERComputed tomography myocardial perfusion imaging

OTHEROxygen 15 labelled water positron emission tomography

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* suspected coronary artery disease

Exclusion criteria

* inability or unwillingness to undergo CT or PET imaging * renal failure (serum creatinine \>200 um/L or eGFR \<30 ml/min) * hepatic failure * allergy to iodinated contrast * pregnancy * contraindication to adenosine * inability to give informed consent * atrial fibrillation with a fast ventricular rate (\>70 beats per minute)

Design outcomes

Primary

Measure	Time frame	Description
Myocardial blood flow	1 month	Myocardial blood flow ( ml/g/min) measured by oxygen-15 water positron emission tomography

Secondary

Measure	Time frame	Description
Fractional flow reserve	1 month	Fractional flow reserve measured during invasive coronary angiography
Myocardial perfusion	1 month	Myocardial perfusion measured as hypoperfusion on adenosine computed tomography myocardial perfusion imaging

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026