Cervical Cancer
Conditions
Keywords
Cervix Uteri
Brief summary
The investigators hope to learn whether perfusion CT is a useful way to assess primary cervical tumor microenvironment and whether there is a relationship between pretreatment perfusion CT measurements and primary cervical tumor size, lymph node involvement (as assessed by standard of care pretreatment fludeoxyglucose Positron emission tomography/CT (FDG-PET/CT)), and treatment response (as assessed by standard of care 3-month post-therapy FDG-PET/CT).
Interventions
None listed
Sponsors
Stanford University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* \>18 years old * with biopsy-proven squamous, adenocarcinoma or adenosquamous cervical cancer * no history of prior pelvic radiation and should be able to receive chemoradiation * non-pregnant women who have not previously undergone a hysterectomy, as that would have removed the cervix. * able to give informed consent
Exclusion criteria
* Subjects whose tumors are not FDG avid on the pre-therapy PET. * Allergy or inability to receive iodinated CT contrast
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measure perfusion in primary cervical tumors using perfusion CT. | 3-6 months | Treatment response will be assessed using a post-treatment FDG-PET/CT to evaluate for complete response, persistent disease or new disease. The association between pre-treatment perfusion CT parameters and response on the post-treatment FDG-PET/CT will be analyzed. |
Countries
United States
Outcome results
None listed