Pacemaker Implantation for Sinus Node Disease
Conditions
Brief summary
Unnecessary right ventricular pacing has been shown to be detrimental in recipients of implantable pacemaker or defibrillators. The ADVANTAGE study evaluates the efficacy of two pacemaker based algorithms (atrioventricular hysteresis function versus mode switch to atrial pacing) to reduce right ventricular pacing.
Detailed description
Comparison of the effect of an atrioventricular hysteresis function with a mode switch to atrial pacing on the right ventricular pacing percentage in a multi-centre, prospective, randomized, single blinded, cross-over study.
Interventions
OTHERpacemaker programming to mode switch to atrial pacing versus atrioventricular hysteresis function
Sponsors
Klinikum Bamberg
Krankenhaus Peißenberg
Medtronic
Deutsches Herzzentrum Muenchen
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Indication for the implantation of a dual-chamber pacemaker
Exclusion criteria
Persistent or permanent atrial tachyarrhythmias atrioventricular block 2nd or 3rd degree indication or the implantation of an defibrillator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Right ventricular pacing percentage | 3 months |
Secondary
| Measure | Time frame |
|---|---|
| BNP levels | 3 months |
Other
| Measure | Time frame |
|---|---|
| Occurrence of atrial tachyarrhythmias | 3 months |
Countries
Germany
Outcome results
None listed