Cardiovascular Disease, Insulin Sensitivity, Type 2 Diabetes
Conditions
Keywords
diacylglycerol oil, insulin sensitivity, type 2 diabetes, cardiovascular disease, risk factors
Brief summary
Diacylglycerol oil has been shown to lower postprandial and fasting serum triacylglycerol levels and reduce body fat. The investigators hypothesize that replacing dietary fat with diacylglycerol oil reduces excess body fat in type 2 diabetic patients and that diacylglycerol oil has a beneficial effect on cardiovascular risk factors in Chinese type 2 diabetic patients.
Interventions
DIETARY_SUPPLEMENTdiacylglycerol oil
DIETARY_SUPPLEMENTtriacylglycerol oil
Sponsors
Zhejiang University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
40 Years to 70 Years
Inclusion criteria
1. Type 2 diabetic patients, blood sugar levels were stabilized between 7.0-10.0 mmol/L 2. Male, aged 40 - 70 years old, Female, aged post-menopausal - 70 years old. 3. Overweight/obese patients (BMI 25 - 40 kg/m2) 4. Currently under diet therapy for diabetes mellitus 5. Understands the procedures and willing to participate in the study
Exclusion criteria
1. Patients who unwilling to give informed consent 2. Type 1 diabetic patients 3. Familial hyperlipemia patients or blood triacylglycerol concentration \> 400 mg/dl 4. Patients with a history of cardiovascular disease and/or arteriosclerotic disease 5. Patients with a history of cerebrovascular disease 6. Patients with serious hepatic disease and/or renal disease 7. Patients with malignancy 8. Participation in another clinical study within 30 days prior to screening period. 9. Has a condition the doctor in charge believes would interfere with evaluation of the subject, or may put subject at undue risk
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| insulin resistance | 120 days |
Outcome results
None listed