Aneurysmal Subarachnoid Haemorrhage, World Neurosurgeon Federation Score ≥ III
Conditions
Keywords
Aneurysmal subarachnoid haemorrhage
Brief summary
Cardiac dysfunction can occur in aneurysmal subarachnoid haemorrhage and might impact patient's neurologic outcome Condition Aneurysmal subarachnoid haemorrhage World Neurosurgeon Federation Score ≥ III
Detailed description
Trans-thoracic echocardiography on day 1, day 3 and day 7 Speckle-Tracking of echocardiographic loops by a cardiologist blinded to the patient's management and outcome
Interventions
PROCEDUREEchocardiography
Speckle-Tracking of echocardiographic loops by a cardiologist blinded to the patient's management and outcome
Sponsors
Nantes University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
15 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Aneurysmal subarachnoid haemorrhage * World Neurosurgeon Federation Score ≥ III * Written information to next-of-kin and patients when possible
Exclusion criteria
* History of myocardial infarction, chronic heart failure with NYHA ≥ 2, major heart surgery * Lack of acoustic window to perform trans-thoracic echocardiography
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neurologic outcome | 3 months | modified Rankin Scale (mRS). Poor neurological outcome was considered as death or severe disability (mRS 5-6). |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between cardiac enzymes (NT-proBNP, troponin T US) and cardiac strain | Day 1 |
| Correlation between EKG findings and cardiac strain | Day 1 |
| Time to amines discontinuation | During Intensive Care Unit stay, expected average 17 days |
| Correlation between cardiac strain on day 1 and Left Ventricular Ejection fraction | Day 1 |
| Length of ICU stay | Duration of ICU stay, expected average 17 days |
| Correlation between Cardiac function and Mechanical Ventilation | Day1, day3, day7 and extubation time expected average 15 days |
| Correlation between Cardiac function and ICU length of stay | Day1, day3, day 7 and end of stay in ICU expected average 17 days |
| Duration of mechanical ventilation | Duration of mechanical ventilation, expected average 15 days |
Countries
France
Outcome results
None listed