Auditory Verbal Hallucinations, Schizophrenia
Conditions
Brief summary
The current study investigates the basic principles that underlie the efficacy of transcranial direct current stimulation for chronic auditory verbal hallucinations in schizophrenia in a multimodal design.
Interventions
DEVICEtDCS
active vs. sham tDCS left hemisphere
Sponsors
Charite University, Berlin, Germany
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* diagnosis of schizophrenia * chronic auditory verbal hallucinations * right-handed
Exclusion criteria
* drug abuse other than nicotine * severe cognitive deficits * severe medical conditions * severe neurological disorders * severe microangiopathy * history of electroconvulsive therapy * pregnancy or lactation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of Auditory Hallucination Rating Scale score | baseline; 3 days after intervention; 3 months after intervention | Auditory Hallucination Rating Scale score will be assessed at baseline; changes thereof at 3 days after intervention and 3 months after intervention are primary outcome measures |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Positive And Negative Syndrome Scale | baseline; 3 days after intervention; 3 months after intervention | Positive And Negative Syndrome Scale score will be assessed at baseline; changes thereof at 3 days after intervention and 3 months after intervention are secondary outcome measures |
Other
| Measure | Time frame | Description |
|---|---|---|
| N1 suppression during talking and listening | baseline; 3 days after intervention | N1 suppression during talking and listening will be assessed at baseline; change thereof at 3 days after intervention is further outcome measure |
| Diffusion Tensor Imaging: Fractional anisotropy of longitudinal superior fascicle and arcuate fascicle | baseline; 3 days after intervention | Fractional anisotropy of longitudinal superior fascicle and arcuate fascicle will be assessed at baseline; change thereof 3 days after intervention is further outcome measure |
| Default Mode Network connectivity | baseline; 3 days after intervention | Default Mode Network connectivity will be assessed at baseline; change thereof 3 days after intervention is further outcome measure |
Countries
Germany
Outcome results
None listed