The Effects of L-arabinose in a Meal in Healthy Men

The Effects of L-arabinose in a Meal on Glucose Metabolism in Healthy Men

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01801540

Enrollment

Registered

2013-02-28

Start date

2010-12-31

Completion date

2011-03-31

Last updated

2013-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glucose Metabolism

Brief summary

The purpose of this study is to investigate the effect of a meal containing different doses of L-arabinose, on the intestinal sucrase activity after intake We measure this by measuring the glucose, insulin and c-peptide after meals. Other measurements are made (glucagon and GLP-1) to explain the correlations.

Interventions

DIETARY_SUPPLEMENTL-arabinose - effect on glucose metabolism

L-arabinose is mixed into the dough of the buns and cup cakes

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

MALE

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy male * normal weight (BMI 18,5-25 kg/m2) * 18-30 years of age

Exclusion criteria

* Not healthy,including those with diabetes Mellitus, high bloodpressure, dyslipidemia or a infectious diseases (hepatitis or HIV), gastrointestinal disorders * Central adipositas (defined as waist circumference \> 94 cm for european men) * Daily intake of vitamins and minerals, 3 months before the trail starts and during the trail. * elevated alcoholcunsumption(\> 21 units af alcohol pr. week) * take medicine * Elite athlete with intensive training * given bloddonation within the last 3 months * smoking

Design outcomes

Primary

Measure	Time frame	Description
Glucose	-15, 0, 15, 30, 45, 60, 90, 120, 180 min	Level of glucose over time, The AUC, the peak value and time to peak
Insulin	-15, 0, 15, 30, 45, 60, 90, 120, 180 min	Level of insulin over time, the AUC, the peak value and time to peak
C-peptide	-15, 0, 15, 30, 45, 60, 90, 120, 180 min	Level of c-peptide over time, The AUC, the peak value and time to peak

Secondary

Measure	Time frame	Description
Glucagon	-15, 0, 15, 30, 45, 60, 90, 120, 180 min	Level of glucagon over time, The AUC, the peak value and time to peak
GLP-1	-15, 0, 15, 30, 45, 60, 90, 120, 180 min	Level of GLP-1 over time, The AUC, the peak value and time to peak

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026