Idiopathic Membranous Nephropathy
Conditions
Keywords
single-nucleotide-polymorphism, Traditional Chinese Medicine, the Comprehensive Treatment Regimen
Brief summary
The purpose of this study is to analysis the different genotype in the idiopathic membranous nephropathy patients which with different therapeutic outcomes after treated by the Comprehensive Treatment Regimen or immunosuppressive agents, and so as to looking for ideal markers to assess appropriate treatment approach and the long-term efficacy.
Detailed description
The primary objective of this study is to looking for the gene level predictors in the patients who suffered from idiopathic membranous nephropathy. And according to the predictors, the clinicians could make a decision which method should be taken on IMN patients, Traditional Chinese Medicine or western medicine, and could get better results.
Interventions
DRUGThe Comprehensive Treatment Regimen of Traditional Chinese Medicine
①ShenQiMoShen Decoction: which plays vital therapeutic effect in the CTR,the dosage is 150ml per serving and two services per day.Dosage and administration:150ml per time,twice per day ②HuoXueTongMai Capsule : which plays a vital role of promoting blood circulation and removing blood stasis. Its main components are the leeches. Dosage and administration: 4 capsules 3 times daily. ③HeiLiaoDou Particle: which will be prescribed when hypoproteinemia (serum albumin concentration≤30g/L)occurred and should be stopped taking until the serum albumin is above 30g/L. Dosage and administration: 2 packages 3 times daily.
DRUGThe immunosuppressive agents
According to Kidney Disease Improving Global Outcomes (KDIGO) clinical practice guideline for glomerulonephritis
Sponsors
Shanghai University of Traditional Chinese Medicine
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Clinical diagnosis of idiopathic membranous nephropathy * Chronic Kidney Disease (CKD)≤3 stage（Glomerular Filtration Rate (GFR)≥30ml/min）and 24 hour urinary protein≥3g * Voluntarily participated in the study and signed an informed consent
Exclusion criteria
* Combined life-threatening complications such as serious infection * Abnormal glucose metabolism * Patients with malignant tumors or malignancy , HIV infection and a history of mental illness , acute central nervous system disease , serious gastrointestinal diseases,etc * Pregnancy or breast-feeding women * Undergoing other clinical trials
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Genome-wide single-nucleotide-polymorphism of IMN patients treated by the Comprehensive Treatment Regimen or conventional approach | one year | Screening for single-nucleotide-polymorphism as the prognostic factor for the TCM intervention of IMN patients. |
Countries
China
Contacts
Primary ContactWang Lin, PHD
Outcome results
None listed