Asthma
Conditions
Keywords
magnesium sulfate, nebulization, lung function
Brief summary
Asthma is a common chronic respiratory illness which results in frequent wheezing, cough,reduced quality of life. Standard treatment for asthma attack includes oxygen therapy, β2-agonists (e.g. albuterol) and inhaled anticholinergics and corticosteroids. Although inhaled short-acting β2-agonists (SAB) is the initial choice to control acute asthma exacerbation, there are still some asthmatic children unresponsive to this management. The Global Initiative in National Asthma (GINA) does not recommend intravenous magnesium sulfate (MgSO4) for routine use in asthma exacerbation especially in young children. But intravenous MgSO4 can reduce hospital admission rates in certain patients due to several effects e.g relaxation of smooth muscle,blocking acetylcholine. In addition,adding MgSO4 to nebulized SAB provides greater benefit in severe asthma exacerbation.
Interventions
Sponsors
Chongqing Medical University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
4 Years to 10 Years
Healthy volunteers
Yes
Inclusion criteria
* asthmatic children with controlled clinical manifestation
Exclusion criteria
* fever * history of chronic disease like bronchopulmonary dysplasia or cystic fibrosis * allergic to acetylcholine, albuterol or magnesium * use any bronchodilator agents before the Clinic day
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| changes of lung function | 10minutes and 20minutes post-dose | to observe changes of Forced expiratory volume in one second and peak expiratory flow in controlled asthmatic children after respectively nebulized MgSO4、albuterol and combination of MgSO4 and albuterol in lung function test. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Nebulized magnesium sulfate alone effectively improve lung function | 10minutes and 20minutes post-dose | After Ach challenge,FEV1 and PEF decreased in all three groups.But only in albuterol and magnesium group,they presented statistically significant while not in combination therapy group.After each intervention, FEV1 and PEF increased.But there was only statistically significant in FEV1 of magnesium and PEF of albuterol at 10 minutes and these two treatment at 20 minutes |
| the number of participants with adverse events as a measure of safety and tolerability | 20minutes | to observe if anyone appear side effects such as nausea, vomiting, hypotension et al in patients who participating in our experiment. we did not found adverse reaction or other side effect in the study. |
Countries
China
Outcome results
None listed