Repeated Implantation Failures
Conditions
Keywords
Failed IVF cycles, IVF outcome parameters, endometrial injury, hysteroscopy, pipelle sampling, Repeated implantation failures
Brief summary
The iatrogenic induction of local endometrial injury caused through hysteroscopy or pipelle sampling in the preceding non- transfer cycle improves the IVF outcome parameters in patients with previous IVF failures.
Detailed description
Endometrial injury was preformed either through hysteroscope during office hysteroscopy through the non touch technique or through pipelle biopsy in the early follicular phase (days 5 to 9) in the preceding cycle of the IVF treatment.
Interventions
PROCEDUREEndometrial injury by hysteroscopy or pipelle sampling
PROCEDUREProceed to COH directly
Sponsors
National and Kapodistrian University of Athens
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
25 Years to 42 Years
Healthy volunteers
No
Inclusion criteria
* Personal history of 2 or more failed IVF/ICSI cycles (RIF) * Age\</= 42 years * Good response with good quality embryos in previous attempts (\>2)
Exclusion criteria
* Personal history of endometrial tuberculosis/ antituberculous treatment * Sonographically detected hydrosalpinges * Intramural fibroids distorting the endometrial cavity, submucous myomas or Asherman's syndrome * Thrombophilia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| positive bHCG rate | through study completion, an average of 2 years |
Secondary
| Measure | Time frame |
|---|---|
| live birth rate | 2 years |
| Ectopic pregnancy rate | 2 years |
| clinical pregnancy rate | 2 years |
| Ongoing pregnancy rate | 2 years |
| Pregnancy complications (preterm birth, placental abnormalities, bleeding throughout pregnancy, pregnancy related hypertensive disorders, IUGR and SGA) | 2 years |
| Miscarriage rate | 2 years |
Countries
Greece
Outcome results
None listed