Intra-abdominal Pressures During the Spontaneous Breathing Trial

Measuring the Change of Intra-abdominal Pressures of the Intensive Care Unit Patients During the Spontaneous Breathing Trial

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01797614

Acronym

IAP_SBT

Enrollment

100

Registered

2013-02-22

Start date

2012-01-31

Completion date

2013-12-31

Last updated

2013-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Failure

Keywords

intra-abdominal pressure, spontaneous breathing trail, weaning

Brief summary

Increased intra-abdominal pressure (IAP) affects pulmonary dynamics. However, little is studied whether pulmonary dynamics affects IAP. We hypothesize that the change of IAP can also reflect the change of pulmonary dynamics. In this study, we choose patients who received spontaneous breathing trial to answer the hypothesis.

Detailed description

During the weaning process, we tapered down the respiratory support from mechanical ventilation and recruited respiratory muscles to work. Previous study showed that transdiaphragmatic pressure was increasing while pressure support was reducing. However, the transdiaphragmatic pressure required invasive procedure to measure and not used frequently in weaning. IAP reflects the pleural pressure. If the PEEP is not changed, change of IAP is largely due to change of transpulmonary pressure. Study Aim: 1. To evaluate the patterns of change of IAP during SBT 2. To predict success of SBT by the change of IAP 3. To predict weaning outcome by the change of IAP

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Adult patients with endotracheal intubation in the intensive care unit * The clinical condition is considered to prepare for weaning assessment

Exclusion criteria

* tracheostomy * severe heart failure, heart disease or arrhythmia * upper airway obstruction related respiratory failure * poor cooperation due to agitation * no foley catheter in place or had been removed * baseline IAP above 20 mmHg

Design outcomes

Primary

Measure	Time frame	Description
To evaluate the patterns of change of IAP during SBT	30min, 60min, 120min	30min, 60min, 120min during a 2-hr SBT

Secondary

Measure	Time frame	Description
To predict success of SBT by the change of IAP	0 min, 30 min, 120 min	To predict success of 2-hour IAP the change of IAP between 0 min and 30 min, and tha change of IAP beween 0 min and 120 min
To predict weaning success by the change of IAP	0 min, 30 min, 120 min	To predict weaning success by the change of IAP between 0 min and 30 min, and tha change of IAP beween 0 min and 120 min

Countries

Taiwan

Contacts

Primary ContactNin-Chieh Hsu, MD

chesthsu@gmail.com886-2-23123456

Outcome results