Insulin Sensitivity of the Human CNS System: fMRI Study With Intranasal Insulin Application

Insulinsensitivität Des Menschlichen Zentralnervensystems: Kernspintomographische Untersuchung Mit Intranasaler Gabe Von Insulin

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01797601

Enrollment

Registered

2013-02-22

Start date

2013-02-28

Completion date

2014-04-30

Last updated

2015-12-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes, Obesity

Brief summary

The purpose of the study is to investigate whether insulin sensitivity and insulin resistance of the human brain is comparable in all insulin sensitive parts of the brain and whether correlates to other phenotypic information (i.e. whole body insulin sensitivity, BMI, age) of the study participants.

Interventions

DRUGHuman Insulin

160 U of insulin

DRUGPlacebo

Insulin dilution medium without insulin

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Normal routine blood works * for women: negative pregnancy test * healthy

Exclusion criteria

* Type 2 diabetes * pregnancy * acute or chronic diseases * Pacemakers * Artificial heart valves * Metal prostheses * Implanted magnetic metal parts (screws, ...) * Metal fragments * Braces * insulin pumps * Tattoos * claustrophobia * reduced temperature sensation and / or increased sensitivity to warming of the body * Ear disease or an increased sensitivity to loud noises

Design outcomes

Primary

Measure	Time frame
Insulin effect on regional brain activity assessed by fMRI	Change from Baseline to 15 minutes and 60 minutes post spray application

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026