Brown Adipose Tissue, Human
Conditions
Keywords
brown adipose tissue, human
Brief summary
About 28 healthy subjects are randomized to 1 hour/day of coldprovocation or to the best of ability to avoid feeling cold, for 6 weeks. Basal metabolic rate and magnetic resonance (for determination of brown adipose tissue volume) imaging are performed before and after the study.
Interventions
Sponsors
University Hospital, Linkoeping
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
healthy subjects -
Exclusion criteria
any significant disease, ot other conditions that interferes with magnetic resonance imaging \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Brown Adipose Tissue, Absolute Volume | Baseline and 6 week | Sub-clavicular brown adipose tissue volume by magnetic resonance imaging (liters) |
Countries
Sweden
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Cold Provocation cold arm
cold arm: 1 hour/day of cold provocation of such an extent that it is unpleasant but does not cause shivering | 16 |
| to Avoid Feeling Cold warm arm
warm arm: To the best of ability avoid feeling cold during 6 weeks | 12 |
| Total | 28 |
Baseline characteristics
| Characteristic | Total | Cold Provocation | to Avoid Feeling Cold |
|---|---|---|---|
| Age, Categorical <=18 years | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical >=65 years | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical Between 18 and 65 years | 28 Participants | 16 Participants | 12 Participants |
| Age, Continuous | 25.3 years STANDARD_DEVIATION 3.5 | 26.1 years STANDARD_DEVIATION 3.9 | 24.3 years STANDARD_DEVIATION 2.9 |
| Region of Enrollment Sweden | 28 participants | 16 participants | 12 participants |
| Sex: Female, Male Female | 16 Participants | 9 Participants | 7 Participants |
| Sex: Female, Male Male | 10 Participants | 5 Participants | 5 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | — / — | — / — |
| other Total, other adverse events | 0 / 16 | 0 / 12 |
| serious Total, serious adverse events | 0 / 16 | 0 / 12 |
Outcome results
Primary
Brown Adipose Tissue, Absolute Volume
Sub-clavicular brown adipose tissue volume by magnetic resonance imaging (liters)
Time frame: Baseline and 6 week
Population: Brown adipose tissue volume (liters)
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Cold Provocation | Brown Adipose Tissue, Absolute Volume | 0.0066 liters | Standard Deviation 0.012 |
| to Avoid Feeling Cold | Brown Adipose Tissue, Absolute Volume | 0.0021 liters | Standard Deviation 0.0086 |