Relationship Between PTEN and Glycemic Variability and Outcome in Critically Ill Patients

Influence of PTEN on Glycemic Variability and Clinical Outcome in the Critically Ill Patient.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01796847

Acronym

GLUPTEN

Enrollment

Registered

2013-02-22

Start date

2012-12-31

Completion date

2015-05-31

Last updated

2017-11-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Critical Illness, Hyperglycemia

Keywords

ICU, Hyperglycemia, Length of stay

Brief summary

Glycemic variability in critically ill patients is a recognized negative prognostic factor. The molecular mechanisms determining inter-patients variability in glucose metabolism during stress are not fully understood. The Phosphatase and Tensin homolog (PTEN) is known to influence glucose homeostasis by interfering in intracellular insulin signaling. Aim of this study is to ascertain whether differential expression of PTEN in critically ill patients correlates with glycemic variability and clinical outcome.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* trauma * provision informed consent

Exclusion criteria

* diabetes * impaired fasting glucose levels

Design outcomes

Primary

Measure	Time frame
Length of ICU stay	Day 1 up to day 28

Secondary

Measure	Time frame
Glycemic variability as expressed by standard deviation of the glycemia measurements	Day 1 up to day 28

Countries

Italy

Outcome results