Child's A to C Cirrhosis, Confirmed Diagnosis of Hepatocellular Carcinoma, Patients Who Are Scheduled to Undergo Transarterial Chemobolization, Systemic Therapy Surgery
Conditions
Brief summary
In patients with HCC undergoing therapy 1. We aim to determine the prognostic significance of liver stiffness in patients with HCC 2. We aim to determine the rate and severity of complications of treatment and its association with liver stiffness in patients with HCC
Interventions
OTHERFibroscan
Sponsors
Chinese University of Hong Kong
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of HCC * Patients who are scheduled to undergo therapy, either TACE systemic therapy or surgery 1. For TACE cohort, patients undergoing first cycle TACE are eligible. 2. For systemic therapy cohort, patients undergoing first-line systemic therapy are eligible. 3. For surgery cohort, patient undergoing surgery are eligible. * Prior surgery or loco-ablative therapy (e.g. Radiofrequency ablation, microwave, percutaneous ethanol injection) is allowed * Child's A to Child's C liver function
Exclusion criteria
* ECOG performance status \> 2 * Poorly controlled ascites
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival | 3 years |
Secondary
| Measure | Time frame |
|---|---|
| Rate and grade of treatment complications | 2 years |
| Liver stiffness (kPa) | 2 years |
Countries
Hong Kong
Outcome results
None listed