The Effect of Simulated Obstructive Apnoea and Hypopnoea on Heart Rhythm in Patients With Paroxysmal Atrial Fibrillation

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01796080

Enrollment

Registered

2013-02-21

Start date

2012-10-31

Completion date

2013-12-31

Last updated

2013-12-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients With Paroxysmal Atrial Fibrillation

Brief summary

In this randomised controlled cross-over study we will investigate whether intrathoracic pressure changes induced by simulated obstructive apnoea and hypopnoea trigger premature supraventricular and ventricular contractions as well as atrial fibrillation in patients with paroxysmal atrial fibrillation.

Interventions

OTHERMueller manoeuvre

OTHERInspiratory threshold

OTHERExpiratory apnoea

OTHERSteady state normal breathing

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

DIAGNOSTIC

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Age 18-75 years * History of ECG-documented paroxysmal atrial fibrillation within the last 12 months and currently in sinus rhythm * Informed consent

Exclusion criteria

* Mental or physical disability precluding informed consent or compliance with the protocol * Amiodarone or Dronedarone medication * Previous radiofrequency ablation for atrial fibrillation * Severe structural heart disease

Design outcomes

Primary

Measure	Time frame
Number of subjects with premature myocardial contractions and/or atrial fibrillation	20 seconds

Secondary

Measure	Time frame
ECG-derived myocardial de- and repolarization times	20 seconds

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026