Endovascular Carotid Surgery, Preoperative Hypotension
Conditions
Keywords
Ephedrine, Phenylephrine, Vasopressor, Carotid surgery, Hypotension, Haemodynamics, Brain ischemia, Tissue perfusion, Stroke, anaesthesia
Brief summary
The effects on brain perfusion of the two currently vasopressors used to treat accidental hypotension occurring during carotid surgery (i.e. ephedrine and phenylephrine) is not known, but a disadvantage to use phenylephrine is suspected, due to its mechanism of action and according to published reports
Detailed description
This is a randomised trial comparing ephedrine and phenylephrine as used for accidental hypotension occurring during carotid surgery, on cerebral perfusion, assessed by near-infrared spectroscopy (NIRS).
Interventions
DRUGephedrine and phenylephrine
Sponsors
University Hospital, Clermont-Ferrand
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age over 18 ASA score I-III Planned carotid endarteriectomy under general anaesthesia Hypotension defined as SAP \< 90 mm Hg during general anaesthesia Informed consent to the trial Protected by the French health welfare
Exclusion criteria
* Emergency surgery Cardiac arrythmia Pregnancy or breastfeeding Allergy to the tested treatment Allergy to hydroxyethylstarch Allergy to the glue of the NIRS's electrodes Current medication: MAOI, intranasal vasopressors
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebral oxygen saturation (SctO2) | at day 1 |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of post-treatment hypotension | At day 1 |
| Incidence of post-treatment bradycardia | at day 1 |
| Postoperative morbidity: cardiovascular, cerebral, renal, surgical | at day 1 |
| Postoperative recovery | at day 1 |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORCharlotte BAUD
University Hospital, Clermont-Ferrand
Outcome results
None listed