Presurgical Language Mapping With fMRI: Comparison of BOLD and fASL Techniques

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01793714

Acronym

MALTA

Enrollment

Registered

2013-02-15

Start date

2014-01-21

Completion date

2017-12-21

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain Neoplasms

Keywords

Magnetic Resonance Imaging

Brief summary

One of the aim of the neurosurgical treatment of brain tumor is to offer the maximal resection with the minimal neurological risk. The presurgical mapping of eloquent areas with functional magnetic resonance imaging (fMRI) is helpful to plan the surgery. BOLD fMRI is now the gold standard to map language areas. However, BOLD signal is diminished near the brain tumor. It is now possible to detect cortical activation with arterial spin labeling (ASL) techniques, detecting variations of perfusion during an activation paradigm (fASL), fASL could be interesting to detect eloquent areas near a brain tumor.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patient 18 years and older * Brain tumor involving frontal and/or temporal lobe and/or insula, with scheduled neurosurgery * Patient able of accepting protocol information * Patient who received information about the protocol and had not expressed its opposition to participate

Exclusion criteria

* Patient with any surgical clip, external clips, or any other ferromagnetic device, that is contraindicated for use in MRI * Claustrophobic patient * Patients who cannot cooperate for the fMRI * Patients subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty

Design outcomes

Primary

Measure	Time frame	Description
Qualitative and quantitative comparison of brain activations obtained with both techniques (BOLD fMRI and fASL)	2 years	Qualitative and quantitative comparison of brain activations obtained with both techniques (BOLD fMRI and fASL) to presurgically detect language areas located near a brain tumor

Secondary

Measure	Time frame	Description
Langage laterality index obtained with both techniques (BOLD fMRI and fASL)and fASL)	2 years	Size and location of activations obtained with BOLD fMRI and fASL in the presurgical detection of language areas
Difference of cerebral blood flow maps obtained with ASL and fASL	2 years	Cerebral blood flow quantification obtained with standard ASL and extracted from fASL

Countries

France

Outcome results