Response to Hyperoxia
Conditions
Brief summary
Our aim is to compare the effects of 80% and 40% Fraction of inspired oxygen on oxidative stress, antioxidant response (in plasma and bronchoalveolar lavage), extubation quality, preanesthetic and postanesthetic expiration tidal volumes.
Interventions
Sponsors
Istanbul University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing abdominal surgery, between 20-60 years old, with American Society of Anesthesiology score I or II
Exclusion criteria
* Patients with Chronic Obstructive Pulmonary Disease, Diabetes Mellitus, muscle-bone diseases, inflammatory bowel diseases and patients with malnutrition. Patients will be recruited through general surgery service of our hospital
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| oxidant and antioxidant response | 4 hours | As primary outcome, the effects of different inspired oxygen fractions on oxidative stress and anti-oxidant response in plasma and bronchoalveolar lavage after intubation and prior to extubation will be evaluated |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hemodynamics | 4 hours | The secondary outcome was evaluating the effects of different inspired oxygen fractions on hemodynamics. |
Countries
Turkey (Türkiye)
Outcome results
None listed