The Effect of Dosage of Caffeine on Intraocular Pressure

The Effect of Dosage of Caffeine on Intraocular Pressure in Healthy Subjects

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01793311

Enrollment

Registered

2013-02-15

Start date

2013-02-28

Completion date

2013-03-31

Last updated

2013-02-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intraocular Pressure, Caffeine Dosage

Keywords

intraocular pressure, caffeine, dosage

Brief summary

The goal of the study is to determine the effect of different doses of caffeine on intraocular pressure. We hypothesized that higher dosage of caffeine would increase intraocular pressure more than lower doses. Eligible subjects will be randomized into three groups: 1. group 1: intake of decaffeinated coffee 2. group 2: intake of coffee with lower caffeine dose 3. group 3: intake of coffee with higher caffeine dose Intraocular pressure will be measured at 0, 30, 60 and 90 minutes after coffee intake.

Detailed description

decaffeinated coffee contains 0.5-2 mg of caffeine regular dose coffee contains 91.8 mg of caffeine high dose coffee contains 144 mg of caffeine all three groups' intraocular pressure will be measured with the Goldmann applanation tonometer at 4 timepoints: 1. 0 minutes (baseline) 2. 30 minutes after intake 3. 60 minutes after intake 4. 90 minutes after intake

Interventions

OTHERdecaffeinated coffee

contains caffeine 0.5-2 mg

OTHERregular dose coffee

contains 91.8 mg of caffeine

OTHERhigh dose coffee

contains 144 mg of caffeine

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy subjects * normal central corneal thickness * normal baseline intraocular pressure

Exclusion criteria

* any ocular disease * baseline intraocular pressure over 21 mmHg * central corneal thickness less than 520 microns or more than 540 microns

Design outcomes

Primary

Measure	Time frame	Description
change from baseline in intraocular pressure (mmHg)after caffeine intake	0, 30 minutes, 60 minutes, 90 minutes post-caffeine intake	intraocular pressure measured at 4 timepoints: 1. 0 minutes (baseline) 2. 30 minutes after intake 3. 60 minutes after intake 4. 90 minutes after intake

Countries

Thailand

Contacts

Primary ContactDamrong Wiwatwongwana, M.D.

samseeha@hotmail.com6653945512

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026