Measuring Corneal Cells With Specular Microscopy

Specular Photomicrograpic Assessment of the Effect of Anti-VEGF Intravitreal Injections on Corneal Thickness and Endothelial Cell Density and Morphology

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01792154

Enrollment

Registered

2013-02-15

Start date

2012-08-31

Completion date

2012-11-30

Last updated

2013-02-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Retinal Diseases

Brief summary

Assess changes in the corneal cell count using Specular Microscopy following tretments with Anti-VEGF injections

Detailed description

Patients with active Wet AMD often receive intraocular Anti-VEGF injections such as Macugen, Lucentis and Avastin on a monthly basis for an extended period of time. While these medications are very effective at controlling the Choroidal Neovascularization associated with this disease, the impact of monthly intravigtreal Anti-VEGF injections on the viability of corneal endothelial cells has yet to be fully characterized. The availability of CESM as a diagnostic test that can be performed quickly and painlessly in the clinic offers a method of tracking corneal endothelial cell count in this patient population.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

50 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Wet Age-related Macular Degeneration * Receiving monthly intraocular injections of Anti-VEGF medication for at least 3 months * Age greater than 50 years of age

Exclusion criteria

* experiences adverse events

Design outcomes

Primary

Measure	Time frame	Description
Specular Photomicrographic Assessment of the Effect of Anti-VEGF Intravitreal injections on corneal thickness and endothelial cell density and morphology	Baseline, Month 6 and Month 12	Changes in corneal endothelial cell density and corneal thickness measured by changes in pachymetry and corneal cell count.

Countries

United States

Outcome results