Single Dose of Etomidate and Adrenal Cortex

the Effect of Single Dose of Etomidate Used During Emergency Intubation on Hemodynamics and Adrenal Cortex: a Randomized Clinical Trial

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01792037

Enrollment

Registered

2013-02-15

Start date

2012-12-31

Completion date

2013-03-31

Last updated

2013-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adrenocortical Deficiency, Hemodynamic Instability

Brief summary

we aim to evaluate the effects of single dose of etomidate or use of steroid prior to etomidate during emergency intubation on hemodynamics and adrenal cortex.

Interventions

DRUGEtomidate

DRUGMidazolam

DRUGmethylprednisolone

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Age

25 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Patients between 25-65 years old with American Society of Anesthesiology scores III or IV that have applied to emergency department and receives an indication for intubation by the intensive care unit physicians will be included to the study

Exclusion criteria

* Patients using steroid prior to the intubation and/or patients with chronical inflammatory diseases will be excluded from the study.

Design outcomes

Primary

Measure	Time frame
effect of use of steroid on adrenal cortex prior to single dose etomidate by comparing cortisol levels	24 hours

Secondary

Measure	Time frame
compare effects of midazolam and etomidate on systemic blood pressure	24 hours

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026