Difference in Measured Results Using Four Different Strokevolume Measurements Simultaneously.
Conditions
Keywords
Left ventricular stroke volume, Arterial waveform analysis, Esofageal doppler, Ultrasound, Cardiac magnetic Imaging, Limits of agreement
Brief summary
Real-time comparison of three different bedside strokevolumemeasurements (arterial waveform analysis, eosofageal doppler and 2D transthoracal ultrasound) validated against cardiac magnetic resonance imaging (CMRI)
Detailed description
20 healthy volounteers between age of 20-40 years, no previous medical history undergo simoultaneous left ventrikular strokevolume measurements using three different methods at rest. After datasampling and without moving, the subject then undergo Cardiac Magnetic Resonance Imaging with 2D-throughplane and cine tecnology for validation of volume measurements. The data is then analyzed using Bland-Altman calculation.
Interventions
PROCEDUREArterial waveform analysis, esofageal doppler, transthoracal cardiac ultrasound, Cardiac magnetic resonance imaging.
Sponsors
University Hospital, Linkoeping
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy volounteers age 20-40, BMI \< 30, weight \< 100 kg, no medications, sinus rythm on ECG, no contra-indications for MRI, ability to give written informed consent. \-
Exclusion criteria
* Heart and/or vascular disease such as angina pectoris, arrythmias, claudicatio intermittens e g. * Diseases in gastrointestinal tract or nose. * Coagulopathies * Pregnancy * Allergys for local anaesthetics * Claustrofobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Limits of agreement (LOA) is less than 30% using CMRI as validation for each individual measurement of left ventricular stroke volume. | Study period (1 month) |
Countries
Sweden
Outcome results
None listed