Hypertensive Patients With Retinal Vein Occlusion
Conditions
Keywords
retinal vein occlusion, systemic hypertension, arteriolar diameter
Brief summary
to evaluate the wall-to-lumen ratio (WLR) of retinal arterioles in hypertensive patients with retinal vein occlusion (RVO) before and after dexamethasone intravitreal implant 0.7 mg (DEX) compared to a matched control group of normal eyes in non-hypertensive subjects.
Interventions
DEVICEDexamethasone Intravitreal Implant (Ozuredex)
Sponsors
Università degli Studi di Brescia
Study design
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ability to provide written informed consent and comply with study assessments for the full duration of the study; * age \> 20 years; * decreased visual acuity as a result of clinically detectable ME associated with either CRVO or BRVO; * the duration of macular edema was required to be between 4 and 24 weeks for both CRVO and BRVO; * retinal thickness in the central subfield (as measured using optical coherence tomography) had to be \> 350 µm in the study eye.
Exclusion criteria
* the
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change of outer arteriolar diameter | the primary endpoint was at 6 months |
| change of inner arteriolar diameter | the primary endpoint was at 6 months |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures were as follows: adverse ocular events; mean change in visual acuity; and mean change in central macular thickness. | Outcomes were analyzed at 4 intermediate time points: 30, 60, 90, and 150 days. |
Countries
Italy
Outcome results
None listed