Bioavailability
Conditions
Keywords
anthocyanin, bioavailability, urine, long-term
Brief summary
Essentially all of the published data on anthocyanin absorption in humans are from short term studies - a few days or less, most typically 24 h. However human studies demonstrating clinical effects are typically conducted for several weeks or even months. To examine how anthocyanin absorption and metabolism may be affected this study will examine urinary excretion of anthocyanins over one month, followed by a one week washout, and then one more dose of blueberry juice.
Interventions
OTHERBlueberry Juice
Dietary intervention
Sponsors
Atlantic Food and Horticulture Research Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Provided written consent (see: Information and Consent Form) * Fluent in English * Complete a confidential medical questionnaire (Appendix 6) * Able and willing to abide by the dietary restrictions as described * Able and willing to abide by the urine collection protocols as described
Exclusion criteria
* No written consent * No confidential medical questionnaire * Unable to comply with diet restrictions and other study requirements
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anthocyanins and Phase 2 anthocyanin conjugates in urine | 5 weeks |
Secondary
| Measure | Time frame |
|---|---|
| White blood cell gene expression at start and end of study | 4 weeks |
Countries
Canada
Outcome results
None listed