Ovarian Neoplasms, Breast Neoplasms, Colorectal Neoplasms, Neoplasms of the Female Genitalia, Lung Neoplasms, Endocrine Gland Neoplasms
Conditions
Keywords
biobank, fresh-frozen tissue
Brief summary
Establishment of a tumor bank, consisting of tissue samples of tumor patients (benign and malign tumors) and healthy people as controls. The tissue samples will be collected systematically together with the corresponding clinical data. The biological samples, the clinical date together with prospective experimental date constitute the entity of the tissue tumor bank. This tumor bank for tissue samples, together with our tumorbank for blood samples (NCT01763125) combined constitute the entity Tumorbank.
Detailed description
Recent progress in diagnosis and therapy of cancer diseases can be ascribed mainly to translational research. The relevance of translational oncology will only increase in the future -From bench to bedside - the swift implementation of new science research results in clinical studies in order to expedite progress in clinical cancer therapy for the benefit of the patient. Its almost a matter of course in the medical science today to collect biological samples together with clinical information thereby creating the foundation for future excellent fundamental research. The aim of this tumor bank is to consist of biological samples (together with a blood bank - see NCT01763125) and isolates of tumor patients and healthy people as controls. The biological samples, the clinical date together with prospective experimental date constitute the entity of the tumor bank. The content of the tumor bank can provide essential material for current and future research (e.g. analyses of prognostic or predictive tumor markers; genetically analysis (polymorphism, mutation, hypermethylation; verification and characterisation of disseminated tumor cells).
Interventions
Tissue sample is collected during therapeutic intervention by a medical doctor/surgeon. Frozen tissue sections are first transferred to Dept.of Pathology. Pathologist samples required tissue to obtain enough evidence for analysis/diagnosis. Rest tumor material with or without malignant cells is tranferred to the lab for Molecular Oncology of Prof.Zeillinger.
OTHERSampling of ascites and pleural effusion
Samples of malignant ascites and/or malignant pleural effusion is only collected during therapeutic intervention from patients at inpatient care.
OTHERCollecting urine samples
Patient is asked to give a urine sample. Urine is collected in urine beaker.
OTHERCollecting saliva sample
Saliva sample is collected by spatula from the mouth cavity of the patient.
OTHERCollecting sputum
Patient is asked to produce sputum into a 50ml lab tube.
OTHERCollecting stool samples
Stool samples are collected prior to bowel preparation for colonoscopy. Device for sampling is provided to the patient.
OTHERLavage/Irrigation
Irrigation liquid is collected during routine therapeutic or diagnostic procedure, e.g. lavage of the uterine cavity and fallopian tubes of women scheduled for surgery.
Sponsors
Medical University of Vienna
Study design
Observational model
CASE_CONTROL
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Male/Female * Age 18 to 90 years max. * Just one current known malignant disease or just one current inflammatory disease
Exclusion criteria
* Inflammatory disease and malignant disease * multiple malignancies * multiple diseases * underage
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Establishment of blood/tissue bank consisting of oncological samples from cancer patients and benign and healthy controls. | 14 years |
Countries
Austria, Belgium, Germany
Contacts
Primary ContactRobert Zeillinger, Prof.Dr.
Backup ContactEva Obermayr, PhD
Outcome results
None listed