Effects of Supplementation With Linseed Oil on Blood Lipids in Vegetarians

Effects of Supplementation With Linseed Oil on Blood Lipids and Fatty Acid Profile in Plasma and Erythrocyte Lipids in Vegetarians

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01788917

Enrollment

Registered

2013-02-11

Start date

2009-09-30

Completion date

2009-12-31

Last updated

2022-10-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inter-conversion n-3 PUFA, Vegetarians

Keywords

n-3 LC-PUFA, vegetarians, fatty acids, blood lipids

Brief summary

The study was performed to investigate the effects of a daily consumption of linseed oil on fatty acid distribution in plasma and red blood cell lipids and blood lipids in vegetarians.

Detailed description

Recent studies suggest that the daily intake of n-3 LC-PUFA (EPA and DHA) can modulate cardiovascular risk factors and prevent lifestyle diseases. The major dietary source of EPA and DHA is seafood (seaweeds and fatty cold water fishes), but they can also be found in lean red meat, in organ meats such as liver and brain. Vegetarians who do not eat meat or fish, have very low or negligible intakes of EPA (\< 5 mg EPA/d) and DHA. The purpose of the present study is to explore the tissue distribution and inter-conversion of ALA to n-3 LC-PUFA as consequence of linseed oil supplementation in vegetarians. Eight vegetarians (3 m; 5 f) who do not eat meat, fish or seaweeds such as algae foods since least two years ago and two subjects (1 m; 1w) who consume the normal western style diet living in Jena (Germany) entered the study. The participants consumed 10 mL linseed oil per day for 10 weeks. The resulting daily dose of ALA was approx. 5.7 g/d.

Interventions

DIETARY_SUPPLEMENTLinseed oil

Dietary supplement: 10 mL linseed oil per day

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* for the vegetarian sub-group : vegetarian diet pattern

Exclusion criteria

* high performance sport, daily alcohol intake and the in-take of dietary supplements (e.g., fish oil capsules) * for the vegetarian sub-group, the consumption of fish and algae products (e.g. seaweeds, sushi)

Design outcomes

Primary

Measure	Time frame
EPA concentrations in plasma lipids and red blood cell lipids	10 weeks

Secondary

Measure	Time frame	Description
blood lipids	10 weeks	total cholesterol, triacylglycerides, high density cholesterol, low density cholesterol, lipoprotein a

Other

Measure	Time frame	Description
parameters of iron status	10 weeks	transferrin, ferritin, transferrin saturation, total ferritin

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026