Genetics and Mechanisms of Rheumatoid Arthritis

Rheumatoid Arthritis Susceptibility Genes in Austrian and Slovak Population

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01788098

Acronym

RASGENAS

Enrollment

790

Registered

2013-02-11

Start date

2009-10-31

Completion date

2012-12-31

Last updated

2013-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Genetic Association Studies, Leukocytes, Mononuclear, Rheumatoid Arthritis

Brief summary

The study is aimed at revealing genetic background in rheumatoid arthritis (RA). For that purpose samples of DNA will be collected from 500 RA patients and similar number of controls from whole Slovakia. Variations in several genes associated with RA will be evaluated. The second aim is to assess functional changes in immune cells from selected patients and their evaluation together with genetic background. The project has observational character without any intention to change the treatment of RA patients.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* rheumatoid arthritis or healthy

Design outcomes

Primary

Measure	Time frame	Description
Genetic association	1 day	Association of selected single nucleotide polymorphisms with rheumatoid arthritis.

Secondary

Measure	Time frame	Description
Peripheral blood mononuclear cells reactivity	1 day	Reactivity and functional changes of peripheral blood mononuclear cells obtained from patients with rheumatoid arthritis in comparison to healthy controls.

Countries

Slovakia

Outcome results