Asthma in Offspring
Conditions
Keywords
Asthma,, acid-suppressing drugs,, pregnancy,, epidemiology
Brief summary
The purpose of this study is 1. To estimate the association between prenatal exposure to proton pump inhibitors (PPIs) and the risk of asthma during childhood. 2. To estimate the association between prenatal exposure to H2-receptor antagonists (H2RAs) and the risk of asthma during childhood.
Detailed description
A cohort study on the association between acid-suppressing drugs in pregnancy and asthma in the offspring
Interventions
DRUGRisk of asthma in offspring
Exposure to PPI or H2RA, respectively during pregnancy No exposure to acid suppressing drugs during pregnancy
Sponsors
AstraZeneca
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
\- Females aged 18-45 years with at least one pregnancy between 1 January 1995 - 31 December 2010 (see study population description)
Exclusion criteria
\- Males, females below age 18 and 45 years and above (see study population description)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relative risk of first asthma diagnosis associated with prenatal exposure to proton pump inhibitors | From 1 January 2005 till 31 December 2010, an expected average of 5 years. |
| Relative risk of first asthma diagnosis associated with prenatal exposure to histamine-2 receptor antagonists | From 1 January 2005 till 31 December 2010, an expected average of 5 years |
Countries
Spain
Outcome results
None listed