Resistant Hypertension
Conditions
Brief summary
Hypertension is a major risk factor for stroke and cardiovascular mortality. Catheter- based renal denervation causes substantial and sustained blood- pressure reduction in patients with resistant hypertension. The purpose of RENSYMPIS is to study the effects of renal denervation on: 1. Cardiovascular function 2. Metabolic factors 3. Inflammatory and endocrine factors 4. Coagulation 5. Sleep
Interventions
PROCEDURERenal Denervation
Sympathetic renal denervation via renal arteries
Sponsors
The Hospital District of Satakunta
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 69 Years
Healthy volunteers
No
Inclusion criteria
* Resistant Hypertension (systolic blood pressure \>160mmHg and 3 or more antihypertensive agents in use) * Age 30- 69 years * Written informed consent
Exclusion criteria
* Secondary hypertension * Pseudohypertension * Pregnancy * Renal insufficiency (GFR \<45ml/min) * Clinically significant stenotic valvular disease * Oral anticoagulation * CCS III-IV symptoms or CABG/PCI in previous 6 months * Prior stroke * Contrast agent allergy * inappropriate renal artery anatomy (\< 4mm diameter, \< 20mm length)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Office blood pressure | 2 years |
Secondary
| Measure | Time frame |
|---|---|
| Ambulatory blood pressure | 2 years |
| Insulin resistance | 2 years |
| Endothelial function | 2 years |
Countries
Finland
Contacts
Primary ContactTuomas Paana, M.D.
Backup ContactAntti Ylitalo, M.D. Ph.D
Outcome results
None listed