Incidence of Retinopathy and Associated Risk Factors in Children and Young Adults With Type 1 Diabetes in Denmark

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01785667

Acronym

DCPD1987

Enrollment

132

Registered

2013-02-07

Start date

2011-01-31

Completion date

2013-02-28

Last updated

2014-07-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetic Retinopathy, Type 1 Diabetes

Brief summary

The objective of this study is to clarify the current diabetic status, including development of complications, in a nationwide cohort of type 1 diabetics, who were last examined together in a large study in 1995. These youngsters were originally participating in a nationwide study of children with type 1 diabetes in Denmark back in 1986. The investigators will try to establish risk factors for developing diabetic retinopathy. The investigators will have emphasis on retinal vessel geometry and the possibilities for early detection of reversible retinal changes, and prediction of other vascular complications.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

25 Years to 45 Years

Healthy volunteers

Inclusion criteria

* Participation in the follow-up study in 1995

Exclusion criteria

* No retinal photographs from 1995

Design outcomes

Primary

Measure	Time frame	Description
Incidence of diabetic retinopathy and proliferative diabetic retinopathy	16 years	Using the ETDRS grading protocol the degree of retinopathy in 2011 will be assessed by grading 7-field fundus photographs taken at follow-up examination. This will be related to the degree of retinopathy found in the patients in 1995, where the last study of the cohort took place.

Secondary

Measure	Time frame	Description
Vessel diameters as a predictor of diabetic retinopathy and proliferative diabetic retinopathy	16 years	Using the computer software named IVAN we will assess the average vessel diameters around the optic disc on fundus photos from 1995. This we will relate to the degree of retinopathy in 2011 to see if vessel diameters predicts diabetic eye complications.

Other

Measure	Time frame	Description
Fractal dimensions as a predictor of diabetic retinopathy and proliferative diabetic retinopathy	16 years	Using the computer software named Fractal Analyzer we will assess the fractal dimension around the optic disc on fundus photos from 1995. This we will relate to the degree of retinopathy in 2011 to see if fractals can help predict diabetic eye complications.

Countries

Denmark

Outcome results