Peritonitis
Conditions
Keywords
peritoneal dialysis, peritonitis
Brief summary
To compare the efficacy of single versus combined antibiotic therapy for bacterial peritonitis in CAPD patients.
Detailed description
To compare relapse and recurrent rate of peritonitis between single and combined antibiotic regimens for bacterial peritonitis in CAPD patients.
Interventions
DRUGceftazidime+ciprofloxacin
2 synergistic antibiotics: ceftazidime IP + ciprofloxacin po for gram negative bacterial peritonitis
DRUGceftazidime monotherapy
ceftazidime IP for gram negative bacterial peritonitis
DRUGcefazolin+gentamicin
cefazolin IP + gentamicin IP for gram positive bacterial peritonitis
DRUGcefazolin monotherapy
cefazolin IP for gram positive bacterial peritonitis
Sponsors
Chulalongkorn University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
15 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* age \>/= 18 years old * ESRD patients on continuous ambulatory peritoneal dialysis more than 4 weeks * presence of symptom or sign of peritonitis * presence of WBC \>100cell/mm3 with PMN \>50% in peritoneal dialysate or gram stain positive for gram positive or gram negative bacteria
Exclusion criteria
* presence of polymicrobial organism, non-fermentative gram negative organism, fungus, mycobacteria in peritoneal fluid or culture-negative * peritonitis from the organisms that required combined antibiotic therapy according to ISPD guideline 2010 * hospital-acquired peritonitis * presence of catheter-related infection * history of peritonitis within 4 weeks * currently taking antibiotic * allergic to the antibiotic that used in the study(penicillin or cephalosporin or quinolone or aminoglycoside)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| relapse or recurrent rate | within 4 weeks after peritonitis treatment |
Countries
Thailand
Outcome results
None listed