Chronic Kidney Disease, Periodontal Disease
Conditions
Keywords
periodontal disease, CKD, nutrition, inflammation, anemia response to ESA, quality of life, hemodialysis
Brief summary
Several studies revealed a direct relationship between the severity of periodontal inflammation and CRP (NHANES III, Dumitriu HT et al, 1998). In patients without any other source of inflammation but PDD, proper dental treatment of the disease decreased CRP to normal levels (Dumitriu H.T. et al., 1998; D'Aiuto F. et al, 2004; Borawski J. et al., 2007) Moreover, a direct link between high levels of CRP and atherosclerotic complications has been found in studies conducted both in general population (Ridker PM, et al., 1998; Koenig W, et al., 1999) and in HD subjects (Westhuyzen J, et al., 2000; Iseki K., et al., 1999; Zimmermann J, et al. 1998).
Detailed description
Patients will be recruited according to eligibility criteria. Initial oral and general status will be evaluated and recorded. The evaluated parameters are listed at the study description section. Also, quality of life will be assessed by using the SF-36 and OHIP-14 questionnaires. Patients will undergo a series of dental interventions with the final scope of eliminating all oral inflammation. Participants will also be instructed regarding correct oral hygiene habits. Following dental and periodontal treatments, the oral and general status will be reassessed and the obtained dat analysed.
Interventions
OTHERDental treatment
1. The preliminary stage deals with: * assessment of the clinical state of the patient by completing a detailed dental and periodontal chart * education of the patient regarding correct oral hygiene habits; 2. Phase I Therapy: * plaque control : removal of dental plaque, calculus and root planning; antimicrobial therapy (local or systemic) * evaluation of response to the treatment 3. Phase II Therapy - surgical phase: * extraction of hopeless teeth * evaluation of the surgical results. 4. Maintenance phase: * periodic reevaluation of plaque and calculus and of periodontal conditions.
Sponsors
Anemia Working Group Romania
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Hemodialyzed patients with periodontal disease
Exclusion criteria
* Malignancies, Diabetes * Patient refusal to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Modification of nutritional status | 6 months | SGA, whole body bioimpedance, biochemical parameters (serum albumin, predialysis serum urea, serum creatinine, serum phosphates) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Modification of inflammatory status | 6 months | C Reactive Protein |
Other
| Measure | Time frame | Description |
|---|---|---|
| Modification of periodontal disease index | 3 months | Modification of periodontal disease index assessed by the CAL, PPD, bleeding index |
| Modification of the quality of life, as assessed by SF-36 and OHIP-14 | 6 months | Modification of the quality of life, as assessed by SF-36 and OHIP-14 |
| Modification of anaemia response to epoetin | 6 months | Modification of anaemia response to epoetin, as assessed by the ERI and by the cumulative ESAs dose |
Countries
Romania
Contacts
Primary ContactOana Slusanschi, DMD
Backup ContactLiliana Garneata, MD
Outcome results
None listed