Neonatal Acute Renal Failure in Preterm
Conditions
Keywords
preterm infants, acute renal failure, nephronic reduction
Brief summary
The aim of this study is to evaluate the signs of nephronic reduction in preterm infants who have presented neonatal acute renal failure. The investigators hypothesize that signs of nephronic reduction would appear earlier in former preterm with neonatal acute renal failure than in control preterm infants.
Detailed description
50 former preterm infants who presented acute renal failure will be evaluated between 3 to 10 years. They will be compared to 25 control former preterm infants without renal dysfunction for signs of nephronic reduction. At inclusion, in order to analyse renal function, all infants will have blood sampling, renal echography and blood pressure measurement. Urine sample will also be collected. Two months later, parents will be informed on the results.
Interventions
OTHERrenal echography
renal echography to analyse the kidney
OTHERBlood sampling
Blood sampling to analyse different parameters of renal function
OTHERcollection of an urine sample
Collection of an urine sample to perform analysis of renal function parameters
OTHERBlood pressure measurement
Sponsors
Nantes University Hospital
Study design
Allocation
NA
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
3 Years to 10 Years
Healthy volunteers
Yes
Inclusion criteria
* For both group of cases (50 infants having presented acute renal failure in preterm) AND group of control cases (25 infants without this) :former preterm infant born before 33 weeks of gestational age between january 2003 and june 2010 and hospitalized in the neonatal intensive care unit of Nantes University Hospital. * Specific to cases: neonatal acute renal failure: serum creatinine\>130 micromol/l from the third day of life. * Control cases: no such renal dysfunction
Exclusion criteria
* no parental consent * other causes of renal failure: congenital uropathy, congenital nephropathy * congenital cardiopathy, polymalformative syndrome
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| microalbuminuria | Day 1 (at inclusion) | The primary outcome of this study is to prove that former preterm infants with neonatal acute renal failure are at higher risk of nephronic reduction than control former preterm infants and that they will present microalbuminuria as earlier sign of nephronic reduction. Precisely, if microalbuminuria divided by creatinuria is above 20mg/g or 2mg/mmol, it will be considered as pathologic. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| measurement of blood pressure | Day 1 (at inclusion) | Evaluation of other renal parameters: blood pressure, renal filtration, tubular functions evaluation of renal size and differentiation by ultrasound |
| measurement of length and volume of kidney by renal echography | day 1 | — |
| creatinine clearance | day 1 | — |
| calciuria | Day 1 | — |
| sodium clearance | day 1 | — |
Countries
France
Contacts
PRINCIPAL_INVESTIGATOREmma ALLAIN-LAUNAY, PH
Nantes University Hospital
Outcome results
None listed