Neuromuscular Block, Dexamethasone, Neuromuscular Block, Recovery
Conditions
Brief summary
The aim of the present study is to compare the time course of a neuromuscular block in patients receiving dexamethasone 8 mg in order to reduce postoperative nausea or vomiting several hours before surgery with patients receiving the drug immediately before induction of anaesthesia and patients without a dexamethasone prophylaxis. The primary end point is the time from start of injection of rocuronium until recovery to a train of four ratio (TOF ratio) of 0.9.
Interventions
None listed
Sponsors
Kreiskrankenhaus Dormagen
Study design
Observational model
CASE_CROSSOVER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* patients aged 18 to 65 years, * American Society of Anesthesiologists Physical Status I or II, * 50-90 kg body weight, * undergoing elective laparoscopic gynaecological surgery in general anaesthesia necessitating intraoperative neuromuscular blockade.
Exclusion criteria
* expected difficulties with endotracheal intubation (history of difficult intubation, * reduced opening of the mouth (\< 2cm), and Mallampati Score of 4), * increased risk of pulmonary aspiration (gastrooesophageal reflux, full stomach, intestinal obstruction), * known allergies to the drugs tested, * pregnancy, * neuromuscular disorders, * intake of drugs affecting neuromuscular blockade, such as furosemide, magnesium or cephalosporins, * hepatic-or renal insufficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the time from start of injection of rocuronium until recovery to a train of four ratio (TOF ratio) of 0.9. | one hour |
Countries
Germany
Outcome results
None listed