Adult Patients, Hypoxemia (Defined by PaO2/FiO2( Fraction of Inspired Oxygen) Below 200), Patient Covered by French Health Care System, Requiring Intubation
Conditions
Keywords
Preoxygenation, Intubation
Brief summary
Prospective, randomized clinical multicentric study, in ICU, during preoxygenation for the intubation of hypoxemic patients.
Detailed description
Prospective randomized clinical multicentric study in ICU, comparing standard oxygenation, high flow nasal oxygen therapy and non invasive ventilation (NIV) , with pulse oxymetry values (SpO2), during preoxygenation for hypoxemic patients
Interventions
PROCEDURE- standard oxygenation
Sponsors
Hopital Gabriel Montpied
University Hospital, Clermont-Ferrand
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* adults patients * requiring intubation and hypoxemia (defined by PaO2/FiO2 below 200) * patient covered by french health care system
Exclusion criteria
* patient refusal * intubation for other causes (excluding hypoxemia) * impossibility to measure pulse oxymetry value * contraindication for NIV : vomiting * NIV intolerance * cardiac arrest during intubation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| least pulse oxymetry value | at day 1 |
Secondary
| Measure | Time frame |
|---|---|
| pulse oxymetry value (at the end of preoxygenation) | at 5 minutes and at 30 minutes after intubation |
| Partial pressure of arterial oxygen (PaO2) | at day 1 |
| Regurgitation rate | at day 1 |
| oxyhemoglobin desaturation below 80 % | at day 1 |
Countries
France
Contacts
Primary ContactPatrick LACARIN
Outcome results
None listed