Excessive Weight Gain During Pregnancy, Gestational Diabetes
Conditions
Keywords
weight gain, healthy lifestyle, gestational diabetes, adipokins, glycemic regulation
Brief summary
The purpose of this study are: * Assess the impact of an intervention to the adoption of healthy lifestyles among pregnant women at high risk of gestational diabetes mellitus on: * weight gain in pregnancy * the levels of maternal and fetal adipokines and * glycemic control maternal and fetal. * Determine whether the adoption of healthy lifestyles in pregnancy is associated with epigenetic changes that influence the levels of adipokines and glucose regulation during pregnancy and in newborns.
Interventions
BEHAVIORALHealthy lifestyle counseling
Nutritionnal and physical activity counseling and physical activity session group
BEHAVIORALControl group
Evaluation of nutritional and physcial activity habits
Sponsors
Diabetes Québec
Fonds de la Recherche en Santé du Québec
Université de Sherbrooke
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* be aged ≥ 18 years, * have a pre-pregnancy BMI ≥ 25 kg/m2, * be at risk of developing a gestational diabetes mellitus (a history of gestational diabetes mellitus or glucose 1 hour post-50g \> 7.1 mmol/L.
Exclusion criteria
* Pre-pregnancy diabetes detected in the first trimester (A1c \> 6.5%, fasting glucose \> 7.0 mmol/L, random blood glucose\> 11.1 mmol/L, glucose \> 10.3 mmol/L 1 hour post-50g) * twin pregnancy * taking medications that can affect blood sugar or weight, * practice ≥ 150 minutes of physical activity per week * against formal-indication for physical activity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight change during pregnancy | Weeks 12, 24, 36 of gestation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Levels of maternal and fetal adipokines | Weeks 12, 24 of gestation and at delivery (in cord blood) | — |
| Maternal and fetal glycemic control | Weeks 12, 24 of gestation and at delivery | Results of glucose tolerance test (50g and 75g) |
| Determine whether the adoption of healthy lifestyle in pregnancy is associated with epigenetic changes that influence the levels of adipokines and glucose regulation during pregnancy and in newborns. | Weeks 12, 24 of gestation and at delivery (cord blood) | — |
| Optimize the intervention before measuring its impact on the prevention of gestational diabetes mellitus on a larger scale. | throughout the study | Documentation will be collected about appreciation of the participants and attendance. |
Countries
Canada
Outcome results
None listed