Stroke
Conditions
Keywords
cortical activation, motor function, activity of daily living
Brief summary
Stroke is the most common cause of motor function impairment. However, the functional impairment is not totally irreversible. Several mechanisms may involved in both the cortical and motor function recovery after onset of stroke, and most of them are related to changes of cortical perfusion and metabolism. Motor function recovery after stroke (especially middle cerebral artery territory lesion) frequently follow stereotypic pattern (brunnström stage). This study is designed to investigate the relationship between motor cortex oxygenation/metabolism and motor function recovery after stroke. To seek if there is similar stereotypic pattern of motor cortex oxygenation/metabolism change during the recover stage after stroke.
Detailed description
Participants receive evaluations (1/week for 3 months period) of * motor function (Include: MMSE, brunnström stage, Fugl-Meyer Assessment of Physical Performance, Box and Block Test of Manual Dexterity, Functional Independence Measure) * cortical perfusion detection during performing limb movements (using NIRS) Then use path analysis to investigate the relationship between motor cortex oxygenation/metabolism and motor function recovery after stroke.
Interventions
PROCEDUREFunctional Electric Stimulation
apply to the hemiplegia affected limbs, helping movement
include occupational therapy and physical therapy
Sponsors
Kaohsiung Veterans General Hospital.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
45 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Ischemic stroke(unilateral, onset within 7 days, without previous stroke history) * Vital sign stable * Upper extremity motor function impairment(brunnström stage I\ III)
Exclusion criteria
* with pacemakers * Seizure history * Serious dysrhythmias * Poor cognition function(MMSE\<13)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cortical activation | weekly changes within 3 months | Using Near-infrared spectroscopy to measure cortical activation changes weekly for 3 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| motor function | weekly changes within 3 months | assess motor function every week for 3 months |
Other
| Measure | Time frame | Description |
|---|---|---|
| Activity of daily living function | weekly changes within 3 months | assess Activity of daily living function weekly for 3 months |
Countries
Taiwan
Outcome results
None listed