Cerebral Reorganization in Schizophrenia

Training-induced Cerebral Reorganization in Schizophrenia

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01781000

Enrollment

Registered

2013-01-31

Start date

2011-12-31

Completion date

2014-04-30

Last updated

2014-11-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia

Keywords

Cognitive Training, Neuroplasticity, MEG, MATRICS

Brief summary

The purpose of this study is to reveal the specific effects of computer-aided cognitive training on cerebral reorganization in schizophrenia

Detailed description

Impairment in cognitive functions is one of the main symptoms in schizophrenia and is currently one of the challenges in the treatment of the disease. In this study we compare effects of two computer-aided training programs. One focused on auditory perception and processing as a basic ability underlying higher order information processing. The other training focus on facial affect discrimination and working memory. Both trainings are computer-aided and time-intensive, including up to twenty sessions within four weeks.

Interventions

BEHAVIORALBrain Fitness & Brain Training- Posit Science

Computer aided cognitive program designed for intensive training of auditory perception, memory and attention

BEHAVIORALFacial Affect Training- FAT

Computer-aided cognitive program designed for intensive training of facial affect discrimination, memory and attention

BEHAVIORALTreatment as usual

standard treatment protocol of schizophrenia ward

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Clinical diagnosis of schizophrenia and disorders with psychotic features * Intact auditory perception * Intact visual perception

Exclusion criteria

* Mental retardation * Age over 60 * Insufficient German language knowledge

Design outcomes

Primary

Measure	Time frame
change from baseline at post-intervention (4-weeks) and 3-months in each to the primary outcome measures: neuropsychological test scores (MCCB), MEG alpha oscillations	baseline, post-intervention (after 4 weeks), 3-months follow-up

Secondary

Measure	Time frame
change from baseline in global functioning (GAF score) at 4 weeks and 3 months	baseline, post-intervention, 3-months follow-up

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026