Relationship Between Vestibular Function and Topographic Memory

The Relationship Between Vestibular Function and Topographic Memory

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01780896

Enrollment

Registered

2013-01-31

Start date

2013-02-28

Completion date

2013-06-30

Last updated

2013-02-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Normal Elderly Population

Keywords

Topographical Memory, Non-Topographical Memory, Vestibular Function, Alzheimer's Disease

Brief summary

The purpose of this study is to evaluate visual and nonvisual topographic memory impairment and its relationship to vestibular function in humans. Topographic memory refers to the ability to remember current and past locations in topographic (navigational) space and to make and/or adjust to spatial transformations using such memories. Performance on each of these topographic memory tasks will be compared to performance on a set of comparable nontopographic memory tasks. Topographic impairments represent some of the earliest cognitive deficits observed in Alzheimer's Disease, and the brain areas involved in topographic memory are the first to show degenerative changes.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

70 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Males or females of all racial and ethnic groups between the ages of 70 and 85 years of age; * Montreal Cognitive Assessment (MOCA) (http://www.mocatest.org) score of \>24; * No known history or current evidence of stroke, trauma, psychiatric illness, or other insult to the brain; * No current use of psychoactive medicine other than caffeine (100 mg/day) or alcohol (1-2 drinks per night); * Normal sleep (at least an average of 7 hours for four days prior to participation); * Able and willing to comply with study requirements including following instructions to complete vestibular and neuropsychological testing; and * Have full understanding of all elements of provide signature and dating of the written informed consent prior to the initiation of procedures specified in protocol.

Exclusion criteria

* \<70 or \>85 yrs of age; * MOCA score of \<25; * History, or current evidence, of stroke, trauma, psychiatric illness, or other insult to the brain; * Prior history of inner-ear balance problems; * Current use of psychoactive medicine other than moderate caffeine or alcohol use; * Acute or chronic sleep deprivation during the week prior to participation (\<7 hours/night on average for four nights prior to participation). Other Restrictions: * No alcohol use on the night before the vestibular testing * 7 hours minimum sleep the night before vestibular testing * No eye make-up can be worn on the day of the vestibular test due to possible interference with vestibular-ocular reflex testing apparatus

Design outcomes

Primary

Measure	Time frame
Determine relationship between topographic memory and vestibular function	14 days

Countries

United States

Contacts

Primary ContactFred Previc, PhD

fprevic@sbcglobal.net210-308-0636

Backup ContactKarl McCloskey

mccloskey@biodevcorp.com(361) 442-7491

Outcome results