Osteosarcoma and Ewing Sarcoma Treatment Response Assessment With Functional MRI Imaging in Children and Young Adults

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01780779

Acronym

FUBEO

Enrollment

Registered

2013-01-31

Start date

2009-06-30

Completion date

2014-06-30

Last updated

2013-01-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ewing Sarcoma, Osteosarcoma

Keywords

Diffusion weighted MRI, Patient outcome assessment, Treatment response, Histopathology

Brief summary

The purpose of the study was to investigate whether functional MRI imaging (diffusion weighted imaging) is useful for monitoring the therapeutic response of bone sarcomas in children and young adults. All patients will be scanned before, during and after chemotherapy. The findings on MRI will be correlated with histological finding after surgery. Second purpose : to define apparent diffusion coefficient value of the bone sarcoma. Third purpose : to try define prognostic factors, to investigate if there is a correlation between early treatment response and outcome.

Interventions

OTHERMRI

MRI exam will be performed in all patients included in the study. The patients will be treated by chemotherapy, defined in the EURO-EWING or EURAMOS protocol. The MR findings will not have any impact on the treatment.

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

6 Years to 30 Years

Healthy volunteers

Inclusion criteria

* Ewing or Osteosarcoma, proven by biopsy and histopathology * all patients are treated by chemotherapy defined by EURAMOS and EURO-EWING protocol

Exclusion criteria

* Patients under the age of 6 years old * patients with contra-indication for MR exam (pace-maker...) * Patients with renal insufficiency * Claustrophobia

Design outcomes

Primary

Measure	Time frame	Description
tumor necrosis - therapy response	6 months	correlation of MRI findings with clinical findings during chemotherapy correlation of diffusion weighted MRI and histopathology results after surgical resection. Calculation of apparent diffusion coefficient : is it a valuable parameter?

Secondary

Measure	Time frame	Description
Prognosis and outcome	2 years	Is there a correlation between early treatment response and outcome? Is diffusion weighted MRI able to predict outcome of the patient (prognostic factor)?

Countries

Belgium

Contacts

Primary ContactSteven Pans, MD

steven.pans@uzleuven.be3216340505

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026