The Efficacy of Hydrolyzed Guar Gum ( PHGG) in the Treatment of Patients With Irritable Bowel Syndrome (IBS)

The Efficacy of Hydrolyzed Guar Gum ( PHGG) in the Treatment of Patients With Irritable Bowel Syndrome- a Double Blind, Placebo - Controlled, Randomized Study

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01779765

Enrollment

130

Registered

2013-01-30

Start date

2013-01-31

Completion date

2014-06-30

Last updated

2014-03-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

IBS

Keywords

IBS, Diarrhea, Constipation, Fibers

Brief summary

This study objective is to assess the short and long term effects of partially hydrolyzed guar gum (PHGG) administration on clinical symptoms of IBS and quality of life of these patients.

Interventions

DIETARY_SUPPLEMENTPHGG

DIETARY_SUPPLEMENTMaltodextrin

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Fulfillment of the Rome III criteria for IBS. * Aged 20-68 years at the time of screening. * Provision of written informed consent. * Commitment of availability throughout the 6 months study period.

Exclusion criteria

* Major abdominal surgery in the past. * The presence of any active (organic)GI disease. * Past or present major medical or psychiatric illness. * Any concomitant disease. * Alarming symptoms (rectal bleeding, weight loss, etc.) * Pregnancy. * Family history of colorectal carcinoma or inflammatory bowel disease (IBD). * Abnormal laboratory studies (blood biochemistry , liver enzymes,complete blood count), abnormal thyroid function. * Non-adjusted diet in the case of lactose or gluten intolerance. * Recent travel to regions with endemic parasitic diseases.

Design outcomes

Primary

Measure	Time frame	Description
Improvement in IBS score.	2 years	IBS scoring - Francis severity IBS score.

Secondary

Measure	Time frame	Description
Quality questionnaire	2 years	Quality of life - by the IBS - quality of life questionnaire - Drossman Patrick.

Countries

Israel

Contacts

Primary ContactNachum Vaisman, MD

vaisman@tasmc.health.gov.il972-3-6974807

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 14, 2026