Rapid Versus Slow Ingestion of Mixed Meal: Influence on Islet and Incretin Hormone Secretion in Healthy Volunteers

Rapid Versus Slow Ingestion of Mixed Meal: Influence on Islet and Incretin

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01779622

Enrollment

Registered

2013-01-30

Start date

2013-06-30

Completion date

2014-06-30

Last updated

2014-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Volunteers Recruited From the General Population

Keywords

mixed meal¨, insulin, glucagon, GIP, GLP-1

Brief summary

To test the influence of rapid versus slow ingestion of a mixed meal on insulin and incretin hormone secretion in healthy volunteers

Detailed description

A mixed meal (524 kcal) is ingested rapidly (within 5 min) or slowly (10-15 min) and changes in insulin, glucagon, GIP and GLP-1 levels are followed for subsequent 300 min

Interventions

OTHERMixed meal

Ingestion of mixed meal

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy subjects

Exclusion criteria

* Diabetes Liver disease Kidney disease Thyroid disease

Design outcomes

Primary

Measure	Time frame
Area under the curve for insulin	300 min

Secondary

Measure	Time frame
Area under the curve for glucose-dependent insuinotropic polypeptide	300 min
Area under the curve for glucagon-like peptide-1	300 min

Other

Measure	Time frame
Area under the curve for glucagon	300 min

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026